Vaping should be ‘promoted’ as smoking cessation aid

Vaping should be ‘promoted’ as smoking cessation aid

October 17 2017 Electronic cigarettes should be promoted as a method of stopping smoking, the...

MHRA issues Drug Safety Updates for loperamide and miconazole

MHRA issues Drug Safety Updates for loperamide and miconazole

October 4 2017 The medicines regulator, the MHRA, has issued Drug Safety Updates on two...

Leo withdraws plans to launch OTC version of Dovonex

Leo withdraws plans to launch OTC version of Dovonex

September 20 2017 Leo Pharma has announced it will not now launch an over-the-counter version of...

Boots introduces generic levonorgestrel for EHC service

Boots introduces generic levonorgestrel for EHC service

September 4 2017 Boots has announced it is starting to make available a cheaper generic...

Which? challenges effectiveness, variety and cost of branded OTC medicines

Which? challenges effectiveness, variety and cost of branded OTC medicines

August 29 2017 Which? has published an article questioning the effectiveness of some over the...

  • Vaping should be ‘promoted’ as smoking cessation aid

    Vaping should be ‘promoted’ as smoking cessation aid

    Tuesday, 17 October 2017 14:31
  • MHRA issues Drug Safety Updates for loperamide and miconazole

    MHRA issues Drug Safety Updates for loperamide and miconazole

    Wednesday, 04 October 2017 16:25
  • Leo withdraws plans to launch OTC version of Dovonex

    Leo withdraws plans to launch OTC version of Dovonex

    Wednesday, 20 September 2017 14:11
  • Boots introduces generic levonorgestrel for EHC service

    Boots introduces generic levonorgestrel for EHC service

    Monday, 04 September 2017 15:09
  • Which? challenges effectiveness, variety and cost of branded OTC medicines

    Which? challenges effectiveness, variety and cost of branded OTC medicines

    Tuesday, 29 August 2017 15:16

Umesh Modi is a chartered accountant, and Pamini Jatheeskumar is a chartered certified accountant at Silver Levene...
  Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead...
Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead pharmacist, Health and Wellbeing Directorate, Public Health England
More inWhite Papers  

a pharmacist consulting with patientOctober 4 2017

The medicines regulator, the MHRA, has issued Drug Safety Updates on two over-the-counter medicines.

 In the first, it has advised that patients taking warfarin should not use over-the-counter miconazole oral gel (Daktarin) available from pharmacies. This follows reports of bleeding events, including some with a fatal outcome in warfarin patients using miconazole oral gel.

If miconazole oral gel is needed for a patient taking an oral anticoagulant, the patient should be closely monitored and the anticoagulant effect carefully titrated, said the MHRA. In addition, health professionals should “advise patients taking prescription-only miconazole oral gel and warfarin that if they experience signs of over-anticoagulation, such as sudden unexplained bruising, nosebleeds, or blood in urine, they should stop using miconazole and seek immediate medical attention.”

The second DSU relates to high doses of loperamide associated with misuse or abuse, and reports of serious adverse cardiac reactions. Reports have been received of high dose loperamide being associated with events such as QT prolongation, torsades de pointes, and cardiac arrest, including some fatalities.

Health professionals are being reminded that naloxone may be used to treat symptoms of loperamide overdose. However, as loperamide’s duration of action is longer than that of naloxone, repeated treatment with naloxone may be necessary, and the patient should be monitored closely for 48 hours, to detect possible CNS depression.

“As for all medicines, pharmacists should remind patients not to take more than the recommended dose on the label,” says the Update.

Links:
MHRA Drug Safety Update – miconazole
MHRA Drug Safety Update – loperamide

OTC News

October 23 2017 The Pharmacists’ Defence Association has warned that the pharmacy regulator may not be doing its utmost to protect public safety.
December 7 2015 Pharmacists in Scotland have been asked to share their views on what politicians need to be made aware of ahead of the Scottish Parliament elections in 2016. The Royal Pharmaceutical Society...