HEE issues medicines management guidance for nursing associates

HEE issues medicines management guidance for nursing associates

February 23 2018 Health Education England has set out educational content expectations for...

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RPS urges community pharmacists to take up free post-registration training

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  • HEE issues medicines management guidance for nursing associates

    HEE issues medicines management guidance for nursing associates

    Friday, 23 February 2018 10:14
  • RPS urges community pharmacists to take up free post-registration training

    RPS urges community pharmacists to take up free post-registration training

    Thursday, 22 February 2018 16:05
  • Which? report claims 'three in 10 pharmacies not following safety guidelines'

    Which? report claims 'three in 10 pharmacies not following safety guidelines'

    Tuesday, 20 February 2018 17:04
  • British Lung Foundation issues pharmacy resources

    British Lung Foundation issues pharmacy resources

    Tuesday, 20 February 2018 16:34
  • CPPE announces patient safety learning campaign

    CPPE announces patient safety learning campaign

    Monday, 19 February 2018 17:29

Umesh Modi is a chartered accountant, and Pamini Jatheeskumar is a chartered certified accountant at Silver Levene...
  Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead...
Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead pharmacist, Health and Wellbeing Directorate, Public Health England
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drugalertJune 27 2016

The tablet and oral suspension preparations of Noxafil (posaconazole) are not interchangeable, the European Medicines Agency has warned. Due to the formulations not having the same pharmacokinetics, there are concerns that patients may be receiving an ineffective dose or overdose if there has been a change from the prescribed formulation.

EMA issued the warning on Friday saying that Noxafil is available as 100mg tablets or as a 40mg/ml oral suspension. The drug is indicated for a number of fungal infections where other antifungal agents are ineffective or not suitable for use, and for prophylactic use in certain other circumstances.

“The recommended oral dosage is 300 mg once a day with the tablets (after a loading dose of 300 mg twice daily on day 1) and 200 mg three to four times a day (600 to 800 mg daily) with the oral suspension,” said EMA. “Medication errors have been reported following erroneous switching, resulting in over or under-dosage and consequent dose-related toxicity or lack of efficacy.

“It is important that the dosage form as well as the relevant dose be specified on the prescription, and that pharmacists ensure the correct oral dosage form is dispensed.”

EMA has said that the Summary of Product Characteristics (SmPC) and patient information leaflet (PIL) for Noxafil are being updated to strengthen warnings about the differences between the two formulations. In addition, “the outer cartons will be revised to further differentiate the two and to include a warning statement that they cannot be simply substituted without adjusting the dose.”

It will be writing to health professionals to remind them of the issue.

Link:

EMA announcement

Practice News

February 23 2018 Health Education England has set out educational content expectations for nursing associates who administer medicines to patients.
February 19 2018 Pharmacists should be receiving educational material this week on a new patient safety campaign from the Centre of Pharmacy Postgraduate Education. Resources have been mailed out ahead...